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Nature: pathophysiological alterations after COVID-19 vaccines

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    #1

    Nature: pathophysiological alterations after COVID-19 vaccines

    Leggetevelo che ne vale la pena.....

    https://www.nature.com/articles/s41421-021-00329-3

    QUA LE CONCLUSIOINI.

    "This is a comprehensive investigation of the pathophysiological changes, including detailed immunological alterations in people after COVID-19 vaccination.

    Results indicated that vaccination, in addition to stimulating the generation of neutralizing antibodies, also influenced various health indicators including those related to diabetes, renal dysfunction, cholesterol metabolism, coagulation problems, electrolyte imbalance, in a way as if the volunteers experienced an infection.

    scRNA-seq of PBMCs from volunteers before and after vaccination revealed dramatic changes in immune cell gene expression, not only echoing some of the clinical laboratory measures but also suggestive of increased NF-κB-related inflammatory responses, which turned out to be mainly taking place in classical monocytes.

    Vaccination also increased classical monocyte contents. Moreover, the gene set positively contributing to MVS scores, also known to be associated with severe symptom development, was highly expressed in monocytes. Type I interferon (IFN-α/β) responses, supposedly beneficial against COVID-19, were downregulated after vaccination.

    In addition, the negative MVS genes were highly expressed in lymphocytes (T, B, and NK cells), yet showed reduced expression after vaccination.

    Together, these data suggested that after vaccination, at least by day 28, other than generation of neutralizing antibodies, people’s immune systems, including those of lymphocytes and monocytes, were perhaps in a more vulnerable state."


    Non so a voi....ma a me sn venuti i peli dritti a leggere quanto sopra..... Sempre più felice di non essermi fatto iniettare stammm💩🖕
    MA ...tanto per la maggioranza di voi... #ANDRATUTTOBENE .....Forse...🤣🤣🤣 👍



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    #2
    I numeri delle persone che manifestano problematiche credo che ancora sia possibile racchiuderli entro l'andamento di quelle che sono le normali patologie a cui la popolazione va incontro.
    Se ( e speriamo veramente di no) i numeri dovessero aumentare, sarà sempre più difficile giustificarli.. anche se già si parla di effetti da long covid.

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      #3
      Originally posted by Funik View Post
      Leggetevelo che ne vale la pena.....

      https://www.nature.com/articles/s41421-021-00329-3

      QUA LE CONCLUSIOINI.

      "This is a comprehensive investigation of the pathophysiological changes, including detailed immunological alterations in people after COVID-19 vaccination.

      Results indicated that vaccination, in addition to stimulating the generation of neutralizing antibodies, also influenced various health indicators including those related to diabetes, renal dysfunction, cholesterol metabolism, coagulation problems, electrolyte imbalance, in a way as if the volunteers experienced an infection.

      scRNA-seq of PBMCs from volunteers before and after vaccination revealed dramatic changes in immune cell gene expression, not only echoing some of the clinical laboratory measures but also suggestive of increased NF-κB-related inflammatory responses, which turned out to be mainly taking place in classical monocytes.

      Vaccination also increased classical monocyte contents. Moreover, the gene set positively contributing to MVS scores, also known to be associated with severe symptom development, was highly expressed in monocytes. Type I interferon (IFN-α/β) responses, supposedly beneficial against COVID-19, were downregulated after vaccination.

      In addition, the negative MVS genes were highly expressed in lymphocytes (T, B, and NK cells), yet showed reduced expression after vaccination.

      Together, these data suggested that after vaccination, at least by day 28, other than generation of neutralizing antibodies, people’s immune systems, including those of lymphocytes and monocytes, were perhaps in a more vulnerable state."


      Non so a voi....ma a me sn venuti i peli dritti a leggere quanto sopra..... Sempre più felice di non essermi fatto iniettare stammm💩🖕
      MA ...tanto per la maggioranza di voi... #ANDRATUTTOBENE .....Forse...🤣🤣🤣 👍

      E' da mesi che gira questo studio (pubblicato a ottobre 2021) e riassumendo dice: "Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection" che in pratica corrisponde "La reazione immunitaria che ti scatena il vaccino è simile a quella data dalla malattia" e grazie al c... aggiungerei io, è così che funzionano i vaccini....

      "A total of 11 healthy adult volunteers of both sexes, aged 24–47 years, with a BMI of 21.5–30.0 kg/m², were enrolled in this study"

      Addirittura 11 persone coinvolte nello studio? Tra l'altro il vaccino vero lo hanno fatto solo a 6 di queste...


      L'abstract poi si conclude con: "Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders." che in pratica è quello che si sta facendo dall'inizio della campagna vaccinale: le persone con condizioni cliniche particolari preesistenti non vengono vaccinate oppure vengono vaccinate e strettamente monitorate. Alcune vengono vaccinate in ospedale per maggior sicurezza
      Last edited by vez1987; 05-04-22, 10:32.

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        #4
        Vedo che hai compreso le conclusioni.....ben specificate a carico del sistema immunitario (che si debilita) e delle varie funzioni organiche che ne risentono...

        Ma x me va bene eh.....le dosi sono tutte vostre 💉👍🤣

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